Workforce Genetics is currently seeking an experienced Process Associate specializing in Cell Culture & Purification.
The core responsibilities will be focused on three key areas:
Cell Culture (Upstream Processing):
• Perform mammalian cell culture operations, including cell line maintenance, seed train expansion, and bioreactor operations (shake flasks, wave bags, and stirred-tank bioreactors).
• Optimize growth conditions and process parameters to improve cell viability and productivity.
• Assist in media preparation, feeding strategies, and metabolite analysis.
• Monitor and document process parameters to ensure consistency and scalability.
Purification (Downstream Processing):
• Perform protein purification using chromatography techniques (affinity, ion exchange, hydrophobic interaction, size exclusion) and filtration methods.
• Optimize purification processes for yield, purity, and scalability.
• Support process development, scale-up, and technology transfer activities.
• Conduct analytical characterization of purified proteins, including SDS-PAGE, Western blot, and UV-Vis spectroscopy.
Documentation and QA:
• Maintain accurate records in lab notebooks and prepare technical reports.
• Ensure compliance with GLP/GMP guidelines, safety protocols, and regulatory standards.
• Support equipment maintenance, calibration, and troubleshooting.
• Collaborate with cross-functional teams in bioprocess development and manufacturing.
Qualifications and Experience:
• Bachelor’s or Master’s degree in Biochemistry, Biotechnology, Chemical Engineering, or a related field.
• 1 + years of experience in cell culture, protein purification, or related bioprocessing.
• Hands-on experience with mammalian cell culture techniques and bioreactor operations.
• Knowledge of protein purification techniques and chromatography principles.
• Experience with monoclonal antibody production and ADC manufacturing.
• Familiarity with process development, scale-up, and technology transfer.
• Experience with process analytical tools (e.g., Bioanalyzer, HPLC, Octet) for protein characterization.
• Understanding of GMP/GLP compliance and regulatory guidelines.